{"id":1268,"date":"2026-02-04T06:06:21","date_gmt":"2026-02-04T06:06:21","guid":{"rendered":"https:\/\/www.pharglass.com\/?p=1268"},"modified":"2026-02-06T05:50:54","modified_gmt":"2026-02-06T05:50:54","slug":"13mm-20mm-butyl-rubber-stopper-rubber-self-healing-injection-ports-solid-seal-for-glass-vial-liquid","status":"publish","type":"post","link":"https:\/\/www.pharglass.com\/fa\/13mm-20mm-butyl-rubber-stopper-rubber-self-healing-injection-ports-solid-seal-for-glass-vial-liquid\/","title":{"rendered":"\u062f\u0631\u067e\u0648\u0634 \u0644\u0627\u0633\u062a\u06cc\u06a9\u06cc \u062e\u0648\u062f\u062a\u0631\u0645\u06cc\u0645\u200c\u0634\u0648\u0646\u062f\u0647 \u0628\u0627 \u067e\u0648\u0631\u062a \u062a\u0632\u0631\u06cc\u0642\u06cc \u0628\u0631\u0627\u06cc \u0648\u06cc\u0627\u0644 \u0634\u06cc\u0634\u0647\u200c\u0627\u06cc\u060c \u0628\u0627 \u0644\u0627\u0633\u062a\u06cc\u06a9 \u0628\u0648\u062a\u06cc\u0644 \u06f1\u06f3 \u0648 \u06f2\u06f0 \u0645\u06cc\u0644\u06cc\u200c\u0645\u062a\u0631\u06cc\u060c \u0622\u0628\u200c\u0628\u0646\u062f\u06cc \u0645\u062d\u06a9\u0645 \u0628\u0631\u0627\u06cc \u0645\u0627\u06cc\u0639"},"content":{"rendered":"
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13mm & 20mm Butyl Rubber Stopper with Self-Healing Injection Port \u2013 Medical-Grade Solid Seal for Glass Vials<\/strong><\/h1>\n\n\n\n

Premium Self-Healing Rubber Stopper<\/strong> with Dual-Lip Design \u2013 Ideal for \u062a\u0632\u0631\u06cc\u0642\u200c\u0634\u062f\u0646\u06cc\u200c\u0647\u0627\u060c \u0648\u0627\u06a9\u0633\u0646\u200c\u0647\u0627 \u0648 \u0628\u06cc\u0648\u0644\u0648\u0698\u06cc\u06a9\u200c\u0647\u0627<\/strong> in Type I Borosilicate Glass Vials<\/strong><\/h2>\n\n\n\n

\u0622\u0646 13mm and 20mm Butyl Rubber Stopper with Self-Healing Injection Port<\/strong> \u0627\u0632 \u0641\u0627\u0631\u06af\u0644\u0633<\/strong> is engineered to deliver superior seal integrity<\/strong>, low extractables<\/strong>, \u060c \u0648 reliable resealing performance<\/strong> after needle penetration. Designed specifically for use in pharmaceutical glass vials<\/strong>, this medical-grade rubber closure<\/strong> features a dual-lip (U-shaped) structure<\/strong> that ensures tight sealing against moisture, oxygen, and microbial ingress \u2014 making it ideal for sterile injectable drugs<\/strong>, mRNA vaccines<\/strong>, \u060c \u0648 lyophilized biologics<\/strong>.<\/p>\n\n\n\n

This solid seal stopper<\/strong> is widely used in multi-dose vials<\/strong> where repeated access via syringe is required. Its self-healing property<\/strong> allows the rubber to close automatically after needle withdrawal, minimizing product leakage and contamination risk \u2014 a critical feature supported by USP<\/strong> \u0648 EP 3.1.9<\/strong> \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f\u0647\u0627.<\/p>\n\n\n\n

\u062a\u0648\u0644\u06cc\u062f \u0634\u062f\u0647 \u062a\u062d\u062a ISO 9001:2015<\/strong> \u0648 GMP-compliant<\/strong> conditions in Henan, China, every stopper undergoes rigorous quality control, including extractables testing<\/strong>, visual inspection<\/strong>, \u060c \u0648 bioburden analysis<\/strong>, ensuring full compliance with global pharmaceutical regulations.<\/p>\n\n\n\n

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\u2705 \u0648\u06cc\u0698\u06af\u06cc\u200c\u0647\u0627\u06cc \u06a9\u0644\u06cc\u062f\u06cc:<\/h3>\n\n\n\n
\u0648\u06cc\u0698\u06af\u06cc<\/th>\u062a\u0648\u0636\u06cc\u062d\u0627\u062a<\/th><\/tr><\/thead>
\u0645\u0648\u0627\u062f<\/strong><\/td>\u0628\u0627 \u062f\u0631\u062c\u0647\u0654 \u067e\u0632\u0634\u06a9\u06cc Butyl Rubber<\/strong>, Bromobutyl<\/strong>, or Chlorobutyl<\/strong> (optional)<\/td><\/tr>
Design Type<\/strong><\/td>Dual-lip \/ U-shaped injection port<\/strong> \u2013 enhances puncture resistance and self-sealing<\/td><\/tr>
Self-Healing Technology<\/strong><\/td>Automatically reseals after needle removal; prevents leakage<\/td><\/tr>
Low Extractables<\/strong><\/td>Minimizes leachables that could affect drug stability or safety<\/td><\/tr>
Moisture Barrier<\/strong><\/td>Excellent protection against humidity ingress<\/td><\/tr>
Customizable Sizes<\/strong><\/td>\u0645\u0648\u062c\u0648\u062f \u062f\u0631 13mm, 20mm, 26mm, 28mm, 32mm<\/strong><\/td><\/tr>
\u06af\u0632\u06cc\u0646\u0647\u200c\u0647\u0627\u06cc \u0631\u0646\u06af<\/strong><\/td>Gray, Red, or Customer Request<\/td><\/tr>
\u067e\u0634\u062a\u06cc\u0628\u0627\u0646\u06cc OEM\/ODM<\/strong><\/td>\u0628\u0644\u0647 \u2013 \u0627\u0646\u062f\u0627\u0632\u0647 \u0633\u0641\u0627\u0631\u0634\u06cc\u060c \u0631\u0646\u06af\u060c \u0686\u0627\u067e \u0644\u0648\u06af\u0648\u060c \u0639\u0645\u0644\u06cc\u0627\u062a \u0633\u0637\u062d\u06cc<\/td><\/tr>
\u0633\u06cc\u0627\u0633\u062a \u0646\u0645\u0648\u0646\u0647\u0654 \u0631\u0627\u06cc\u06af\u0627\u0646<\/strong><\/td>\u0646\u0645\u0648\u0646\u0647\u200c\u0647\u0627\u06cc \u0631\u0627\u06cc\u06af\u0627\u0646 \u0628\u0631\u0627\u06cc \u0622\u0632\u0645\u0648\u0646 \u0633\u0627\u0632\u06af\u0627\u0631\u06cc \u062f\u0631 \u062f\u0633\u062a\u0631\u0633 \u0647\u0633\u062a\u0646\u062f.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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Technical Specifications: 13mm & 20mm Self-Healing Rubber Stopper<\/strong><\/h2>\n\n\n\n
\u067e\u0627\u0631\u0627\u0645\u062a\u0631<\/strong><\/th>\u0645\u0634\u062e\u0635\u0627\u062a<\/strong><\/th><\/tr><\/thead>
\u0646\u0627\u0645 \u0645\u062d\u0635\u0648\u0644<\/strong><\/td>13mm 20mm Butyl Rubber Stopper with Self-Healing Injection Port<\/td><\/tr>
\u0634\u0645\u0627\u0631\u0647 \u0645\u062f\u0644<\/strong><\/td>03<\/td><\/tr>
\u0646\u0627\u0645 \u062a\u062c\u0627\u0631\u06cc<\/strong><\/td>\u0641\u0627\u0631\u06af\u0644\u0633<\/strong><\/td><\/tr>
\u0645\u0648\u0627\u062f<\/strong><\/td>Butyl Rubber<\/strong>, Bromobutyl Rubber<\/strong>, Chlorobutyl Rubber<\/strong><\/td><\/tr>
\u0631\u0646\u06af<\/strong><\/td>Gray, Red, or Custom<\/td><\/tr>
Sizes Available<\/strong><\/td>\u06f1\u06f3 \u0645\u06cc\u0644\u06cc\u200c\u0645\u062a\u0631<\/strong>, \u06f2\u06f0 \u0645\u06cc\u0644\u06cc\u200c\u0645\u062a\u0631<\/strong>, 26mm, 28mm, 32mm<\/td><\/tr>
\u0645\u062d\u0644 \u0645\u0646\u0634\u0627\u0621<\/strong><\/td>\u0647\u0646\u0627\u0646\u060c \u0686\u06cc\u0646<\/td><\/tr>
\u0645\u0635\u0631\u0641<\/strong><\/td>Primary closure for glass vials<\/strong> (injectables, vaccines, biologics)<\/td><\/tr>
\u062e\u062f\u0645\u0627\u062a \u067e\u0631\u062f\u0627\u0632\u0634<\/strong><\/td>Precision compression molding<\/td><\/tr>
\u0628\u0633\u062a\u0647\u200c\u0628\u0646\u062f\u06cc<\/strong><\/td>Plastic Bag + Export Carton<\/td><\/tr>
\u062d\u062f\u0627\u0642\u0644 \u0633\u0641\u0627\u0631\u0634<\/strong><\/td>\u06f1\u06f0\u066c\u06f0\u06f0\u06f0 \u0639\u062f\u062f<\/td><\/tr>
Sample Availability<\/strong><\/td>Free Samples<\/td><\/tr>
\u067e\u0634\u062a\u06cc\u0628\u0627\u0646\u06cc OEM\/ODM<\/strong><\/td>\u0642\u0627\u0628\u0644 \u0642\u0628\u0648\u0644<\/td><\/tr>
\u0648\u06cc\u0698\u06af\u06cc<\/strong><\/td>Medical Grade<\/strong>, Self-Healing<\/strong>, Solid Seal<\/strong>, Low Extractables<\/strong><\/td><\/tr>
\u0627\u0646\u062f\u0627\u0632\u0647 \u0628\u0633\u062a\u0647\u0654 \u062a\u06a9\u06cc<\/strong><\/td>\u06f1\u06f0\u00d7\u06f2\u06f0\u00d7\u06f1\u06f5 \u0633\u0627\u0646\u062a\u06cc\u200c\u0645\u062a\u0631<\/td><\/tr>
\u0648\u0632\u0646 \u0646\u0627\u062e\u0627\u0644\u0635<\/strong><\/td>\u06f1\u066c\u06f0\u06f0\u06f0 \u06a9\u06cc\u0644\u0648\u06af\u0631\u0645 \u0628\u0647 \u0627\u0632\u0627\u06cc \u0647\u0631 \u0648\u0627\u062d\u062f<\/td><\/tr>
\u06af\u0648\u0627\u0647\u06cc\u0646\u0627\u0645\u0647\u200c\u0647\u0627<\/strong><\/td>ISO 9001:2015<\/strong>, ISO 14001<\/strong>, OHSAS 18001<\/strong><\/td><\/tr>
\u062a\u0637\u0628\u06cc\u0642 \u0628\u0627 \u0645\u0642\u0631\u0631\u0627\u062a<\/strong><\/td>USP<\/strong>, EP 3.1.9<\/strong>, JP XVII<\/strong>, FDA 21 CFR 177.1520<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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Why This Design Matters: The Science Behind the Dual-Lip Structure<\/strong><\/h2>\n\n\n\n

\u0622\u0646 U-shaped (or dual-lip)<\/strong> design of this rubber stopper<\/strong> is not just aesthetic \u2014 it\u2019s a functional innovation<\/strong> that improves performance in several key areas:<\/p>\n\n\n\n

\ud83d\udd39 Enhanced Puncture Resistance<\/strong>: The two raised lips distribute needle pressure evenly, reducing deformation and improving durability during multiple withdrawals.
\ud83d\udd39 Improved Re-Sealability<\/strong>: After needle withdrawal, the elastic rubber returns to its original shape, forming a tight seal<\/strong> without gaps.
\ud83d\udd39 Reduced Risk of Product Loss<\/strong>: Critical for high-cost biologics<\/strong> \u0648 \u0648\u0627\u06a9\u0633\u0646\u200c\u0647\u0627<\/strong>, where even minor leakage can lead to waste or contamination.<\/p>\n\n\n\n

According to a study published in \u0645\u062c\u0644\u0647 \u0639\u0644\u0648\u0645 \u062f\u0627\u0631\u0648\u06cc\u06cc<\/em> (2021), U-shaped stoppers reduce leakage rates by up to 40%<\/strong> compared to flat-faced designs in multi-dose applications.<\/p>\n\n\n\n

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Material Comparison: Which Rubber Is Right for Your Formulation?<\/strong><\/h2>\n\n\n\n
Rubber Type<\/strong><\/th>\u0628\u0647\u062a\u0631\u06cc\u0646 \u0628\u0631\u0627\u06cc<\/strong><\/th>\u0645\u0632\u0627\u06cc\u0627\u06cc \u06a9\u0644\u06cc\u062f\u06cc<\/strong><\/th><\/tr><\/thead>
Butyl Rubber<\/strong><\/td>General injectables, liquid formulations<\/td>Cost-effective, good elasticity, low gas permeability<\/td><\/tr>
Bromobutyl Rubber<\/strong><\/td>\u0648\u0627\u06a9\u0633\u0646\u200c\u0647\u0627<\/strong>, \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0632\u06cc\u0633\u062a\u06cc<\/strong>, multi-dose vials<\/strong><\/td>Enhanced chemical resistance, better adhesion to aluminum seals<\/td><\/tr>
Chlorobutyl Rubber<\/strong><\/td>Lyophilized (freeze-dried) products<\/strong><\/td>Superior moisture barrier<\/strong>, lowest extractables profile<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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\u062a\u0648\u062c\u0647<\/strong>: For freeze-dried (lyophilized)<\/strong> products, we recommend chlorobutyl rubber<\/strong> due to its excellent moisture barrier properties<\/strong> \u0648 low extractables<\/strong>, as confirmed by studies in European Journal of Pharmaceutics<\/em>.<\/p>\n<\/blockquote>\n\n\n\n

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\u0628\u0631\u062a\u0631\u06cc\u0646 \u06a9\u0627\u0631\u0628\u0631\u062f\u0647\u0627 \u062f\u0631 \u062f\u0627\u0631\u0648\u0633\u0627\u0632\u06cc \u0648 \u0632\u06cc\u0633\u062a\u200c\u0641\u0646\u0627\u0648\u0631\u06cc<\/strong><\/h2>\n\n\n\n